M.D. Anderson Statistical Software Library-- A large collection of free statistical software (almost 70 programs!) from the Biostatistics and Applied Mathematics department of the M.D. Anderson Cancer Center. Software is distributed in the form of program source files and/or self-extracting archives of executable programs for Windows, Mac, Unix/Linux environments.
Lifetables -- Windows program for Mortality Analysis for Demography and Epidemiology. The program will calculate the life expectancy, including all intermediary statistics, variance an confidence interval for the life expectancy, Potential Gains in Life Expectancy (PGLE), Years of Potential Life Lost (YPLL) and Lifetime Years of Potential Life Lost (LYPLL). YPLL can be calculated adjusted for competing causes of mortality and both YPLL and LYPL can also be discounted. Two populations can be compared using direct and indirect standardization, the SMR and CMF and by comparing two lifetables. Confidence intervals and statistical test are provided. There is an extensive helpfile in which everything is explained. From the Downloads section of the QuantitativeSkills web site.
Sample Size for Microarray Experiments -- compute how many samples needed for a microarray experiment to find genes that are differentially expressed between two kinds of samples (e.g.: cancer vs. normal tissue), by performing separate gene-by-gene t-tests. You specify how many genes you're looking at, how many false positives you are willing to accept, how large a difference you want to be able to detect (as the fold difference between the two kinds of samples), the power of the test (% of differentially expressed genes likely to be detected by the experiment), and an estimate of the logarithmic SD of the gene intensities.
MIX (Meta-analysis with Interactive eXplanations) -- a statistical add-in for Excel 2000 or later (Windows only). Ideal for learning meta-analysis (reproduces the data, calculations, and graphs of virtually all data sets from the most authoritative meta-analysis books, and lets you analyze your own data "by the book"). Handles datasets with dichotomous & continuous outcomes; calculates Risk Diff, RR, OR, Mean Diff, Hedges's g, Cohen's d; performs standard & cumulative meta-analysis with CI ,z & p; fixed and random effects modeling; Cochran's Q with p-value; Higgins's I2 and H with CI; and publication bias tests: Rank correlation (tau-b) test with z & p, Egger's and Macaskill's regression tests with CI, and Trim-and-Fill. Generates numerous plots: tandard and cumulative forest, p-value function, four funnel types, several funnel regression types, exclusion sensitivity, Galbraith, L'Abbe, Baujat, modeling sensitivity, and Trim-and-Fill.
EWOC - Escalation With Overdose Control -- a Bayesian method for selecting dose levels in Phase I Clinical Trials while controlling the probability of exceeding the maximum tolerated dose. This is a stand-alone Windows (95 through XP) program that receives information about dose-limiting toxicities (DLTs) observed at some starting dose, and calculates the doses to be administered next. DLT information obtained at each dosing level guides the calculation of the next dose level. (For some strange reason, the EWOC download web site does not work properly with the FireFox web browser; but it does work with MS Internet Explorer.)
STPLAN -- Performs power, sample size, and related calculations needed to plan studies. Covers a wide variety of situations, including studies whose outcomes involve the Binomial, Poisson, Normal, and log-normal distributions, or are survival times or correlation coefficients. Available for MS-DOS and Mac; also as Fortran and C source code.
Epi InfoVersion 3.5.1 -- Public domain statistical software for epidemiology developed by Centers for Disease Control and Prevention (CDC) in Atlanta, Georgia (USA). Epi Info has been in existence for over 20 years and is currently available for Microsoft Windows. The program allows for data entry and analysis. Within the analysis module, analytic routines include t-tests, ANOVA, nonparametric statistics, cross tabulations and stratification with estimates of odds ratios, risk ratios, and risk differences, logistic regression (conditional and unconditional), survival analysis (Kaplan Meier and Cox proportional hazard), and analysis of complex survey data. The software is in the public domain, free, and can be downloaded from http://www.cdc.gov/epiinfo. Limited support is available.
PEPI -- a collection of 43 small DOS / Windows programs that perform a large assortment of statistical tests. They can be downloaded individually, or as a single ZIP file.
Free Public Health & Epidemiology Software -- written by Mark Myatt)and others:
- WINPEPI (PEPI for Windows) -- Windows versions of the renowned PEPI suite of programs. A freely-accessible article describing the new features of WinPEPI can be accessed here.
- EpiCalc 2000 -- Statistical calculator
- FP Advisor -- Foodborne disease database
- SigmaD -- Standardisation of measurement
- SOUNDEX Calculators -- Confidentiality of data / identification of duplicate records
- SampleXS -- Sample size calculator for cross-sectional surveys
- SampleLQ -- Sample size calculator for LQAS surveys
- SampleRate -- Sample size calculator for a single rate
- EpiGram -- Simple diagramming software
- Statistical Utilities -- Miscellaneous statistical and epidemiological utilities (by Ray Simons and others)
- EpiInfo PLUS -- A version of the classic DOS version of EpiInfo
- EpiInfo Add-ins -- Logistic regression and survival analysis for EpiInfo .REC files
- MUAC screening tool -- Software to determine MUAC cut-points for two-stage screening in nutritional emergencies.
- CSAS coverage calculator -- An Excel spreadsheet for calculating coverage estimates and drawing plots and maps from CSAS survey data. Also provides capture-recapture estimates of the sensitivity of a case-finding procedure. A spreadsheet containing example data is available here.
- A brief introduction to using the R environment for analysing epidemiological data in Adobe Acrobat (.PDF) format with sample data, in a ZIP file here.
ARIMA -- a seasonal adjustment program for PC and Unix, developed by the Census Bureau.
DEMETRA -- (Win 9x/NT) a user-friendly interface to the seasonal adjustment methods TRAMO/SEATS and X-12-ARIMA . Developed by Eurostat to facilitate the application of these modern time series techniques to large-scale sets of time series and in the explicit consideration of the needs of production units in statistical institutes. Client/server architecture can access various kinds of databases and files. Contains two main modules: seasonal adjustment and trend estimation with an automated procedure (e.g. for unexperienced users or for large-scale sets of time series), and with a user-friendly procedure for detailed analysis of single time series.
Meta-analysis 5.3 -- Free DOS statistics software for meta-analysis. Probably still the most frequently used meta-analysis software in the world. Can select the analysis of exact p values or effect sizes (d or r, with a cluster size option). Can plot a stem-and-leaf display of correlation coefficients. A utility menu is provided that allows various transformations and preliminary computations that are typically required before the final meta-analysis can be performed.
EasyMA -- a free user-friendly MS-DOS program for the meta-analysis of clinical trials results. Developed to help physicians and medical researchers to synthesize evidence in clinical or therapeutic research.
EPIMETA (from CDC) -- a DOS-based meta-analysis program that features a Windows-like interface which makes data entry, file manipulation, and subgroup analysis easy.
Life Table -- available in Lotus and Excel formats.
ABSRISK -- a program (MS-DOS) for estimating absolute risks from relative risks. Uses age-specific mortality and morbidity data to convert relative risk estimates into absolute risk estimates. That is, it estimates the probability that a patient will suffer a specific morbid or mortal outcome in a given time interval. The user first specifies a data file that contains the needed mortality and morbidity data for the disease of interest. She then gives her patient's age and relative risk, and the time interval over which the risk estimate is to be derived. The program derives this risk, which is given both interactively and in a log file.
Biodiversity Research Software -- Five software packages, with documentation:
- LUMP, LINK, and JOIN: Utility Programs for Biodiversity Research
- COLLECT1 and COLLECT2: Programs for Calculating Statistics of Collectors' Curves
- BOUNDARY: A Program for Detecting Boundaries in Ecological Landscapes
- EXTSPP1 and EXTSPP2: Programs for Comparing and Performance-Testing Eight Extrapolation-Based Estimators of Total Taxonomic Richness
- RARE, SPPDISS, and SPPRANK: Programs for Detecting Between- Sample Differences in Community Structure
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